BRIEF REPORT: CLINICAL SCIENCE Time to Initiation of Antiretroviral Therapy Among Patients With HIV-Associated Tuberculosis in Cape Town, South Africa
نویسندگان
چکیده
We studied the time interval between starting tuberculosis treatmentandcommencingantiretroviral treatment (ART)inHIV-infected patients (n = 1433; median CD4 count 71 cells per microliter, interquartile range: 32–132) attending 3 South African township ART services between 2002 and 2008. The overall median delay was 2.66 months (interquartile range: 1.58–4.17). In adjusted analyses, delays varied between treatment sites but were shorter for patients with lower CD4 counts and those treated in more recent calendar years. During the most recent period (2007–2008), 4.7%, 19.7%, and 51.1% of patients started ART within 2, 4, and 8 weeks of tuberculosis treatment, respectively. Operational barriers must be tackled to permit further acceleration of ART initiation as recommended by 2010 WHO ART guidelines.
منابع مشابه
Time to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africa.
We studied the time interval between starting tuberculosis treatment and commencing antiretroviral treatment (ART) in HIV-infected patients (n = 1433; median CD4 count 71 cells per microliter, interquartile range: 32-132) attending 3 South African township ART services between 2002 and 2008. The overall median delay was 2.66 months (interquartile range: 1.58-4.17). In adjusted analyses, delays ...
متن کاملComplications of Antiretroviral Therapy Initiation in Hospitalised Patients with HIV-Associated Tuberculosis
BACKGROUND HIV-associated tuberculosis is a common coinfection in Sub-Saharan Africa, which causes high morbidity and mortality. A sub-set of HIV-associated tuberculosis patients require prolonged hospital admission, during which antiretroviral therapy initiation may be required. The aim of this study was to document the causes of clinical deterioration of hospitalised patients with HIV-associa...
متن کاملParadoxical worsening of Emergomyces africanus infection in an HIV-infected male on itraconazole and antiretroviral therapy
1 Department of Medicine, University of Cape Town, Cape Town, Western Cape, South Africa, 2 Department of Dermatology, University of Cape Town, Cape Town, Western Cape, South Africa, 3 Department of Anatomical Pathology, National Health Laboratory Service Groote Schuur Hospital Branch, Cape Town, Western Cape, South Africa, 4 Division of Infectious Diseases & HIV Medicine, Department of Medicin...
متن کاملTemporal trends in TB notification rates during ART scale-up in Cape Town: an ecological analysis
INTRODUCTION Although antiretroviral therapy (ART) reduces individual tuberculosis (TB) risk by two-thirds, the population-level impact remains uncertain. Cape Town reports high TB notification rates associated with endemic HIV. We examined population trends in TB notification rates during a 10-year period of expanding ART. METHODS Annual Cape Town TB notifications were used as numerators and...
متن کاملThe case for integrating tuberculosis and HIV treatment services in South Africa.
Integration of human immunodeficiency virus (HIV) and tuberculosis (TB) services is critical to effectively addressing both epidemics in South Africa. Examples of the specific need to integrate TB and HIV services are presented from a community in Cape Town, South Africa, with high burdens of HIV infection and TB and from an antiretroviral therapy (ART) program in a peri-urban township. TB and ...
متن کامل